Rifaximin (brand name Xifaxan) is a non-systemic, gastrointestinal-selective antibiotic used to treat traveler’s diarrhea, irritable bowel syndrome with diarrhea (IBS-D), and to reduce the risk of overt hepatic encephalopathy (OHE) recurrence. It works by killing bacteria in the gut, with common side effects including nausea, dizziness, fatigue, and peripheral edema













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